Concomitant occurrence of cryptococcal meningitis and tuberculous meningitis in a HIV-negative patient with alcoholic cirrhosis and Pott?s spine

摘要

Cryptococcus neoformans is an encapsulated yeast that causes serious infections in immunocompromised populations. The majorityof cases occur in HIV-infected individuals. Mycobacterium tuberculosis is another very common opportunistic infectious agent inHIV population as well as in immunocompetent population. Many cases of mixed infections have also been reported inimmunocompromised patients especially HIV-positive patientsbut all of them having infections at two different sites. Mixed CNSinfections in a HIV-negative patient has never been reported before. We report here a case of a 41-year-old, HIV-negative manwith alcoholic liver cirrhosis with chronic hepatitis C who presented with seizure and unconsciousness. Cryptococcal meningitiswith tuberculous meningitis (cerebral tuberculosis) with Pott's spine was diagnosed, and despite adequate treatment the patientdeveloped multi-system organ failure and eventually expi