Effect of Essential Oil of Leaf and Aerial Part of Rosmarinus officinalis on Passive Avoidance Memory in Aged and Young Mice

摘要

BackgroundandObjective:Inthisstudy,theeffectofessentialoilofaerialpartofRosmarinusofficinalis,whichisrichofantioxidants,wasinvestigatedonmemoryofyoungandagedmicewithpassiveavoidanceapparatus.MaterialsandMethods:Fivegroupsofeachyoungandagedmice(n=8)wereselectedforthisstudy.AlldosesofessentialoilsofleafandaerialpartofRosmarinusofficinalis(200,400,600,800mg/kg)wereinjectedintraperitoneallyonceadayfor7daystofourgroupsofageandyoungmiceandfifthgroup(control)received10ml/kgdistilledwateroncedailyfor7days.Results:Meanofstep-downlatencyonday4incomparisonwithday2becamesignificantlylonger(P0.05)inallyoungandagedgroupsofmice.Ontheotherhand,themeanofstep-downlatencyinallgroupsreceiveddifferentdosesofessentialoiltocomparewithcontrolgroupshowedsignificant(P0.05)improvementinmemorytestinday4.Alsoinallagedgroupreceiveddifferentdosesofessentialoilstep-downlatencyweresignificantly(P0.05)longerthanyounggroups.Conclusion:Theresultshowedthat,theessentialoilofRosmarinusofficinalisimprovesmemoryinallyoungandagedanimalgroups,butitwasmoreeffectiveonagedmice.