首页> 外文期刊>Journal of Young Pharmacists >Gel Formulation Containing Microcapsules of Grape Seed Oil (Vitis vinifera L.) for Skin Moisturizer
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Gel Formulation Containing Microcapsules of Grape Seed Oil (Vitis vinifera L.) for Skin Moisturizer

机译:含有葡萄籽油(Vitis vinifera L.)微胶囊的凝胶制剂,可用于皮肤保湿

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Objective: Grape seed oil (GSE) from Vitis vinifera L. has a high linoleic acid content, which plays a role in the skin moisturizing. However, linoleic acid is a liquid form and easily oxidized. The aims of this research were to prepare the microcapsules of GSE using ethylcellulose as coating polymer, and to formulate the gel containing the GSE microcapsules. Method: GSE microcapsules were prepared by solvent evaporation method with ethylcellulose in the ratio of 1:1, 1:2, 1:3 and 1:4 based on the amount of oil and polymer ratio. The produced GSE microcapsules were characterized such as the morphology, entrapment efficiency, particle size, and swelling index. The best microcapsules were formulated into a gel dosage form, and then evaluated. Results: The results showed that the microcapsules had a spherical shape and exhibited no pores, with the entrapment efficiency was in the range of 45.81 to 93.87%. The mean volume diameters of F1, F2, F3, and F4 microcapsules were 83.58 nm, 129.40 nm, 151.15 nm and 202.74 nm, respectively. The microcapsules showed the swelling index in the range of 49-73%. Furthermore, the gel containing 2% GSE microcapsules showed a good appearance and viscosity of 10,800 cps with plastic flow property. Conclusion: The F4 microcapsules of GSE, which the ratio of GSE and ethylcellulose was 1:4, was the best microcapsules with the entrapment efficiency of 93.87%. The GSE microcapsules that was incorporated into a gel formulation would be an interesting cosmetic product for skin moisturizer.
机译:目的:来自葡萄(Vitis vinifera L.)的葡萄籽油(GSE)具有较高的亚油酸含量,在皮肤保湿中起作用。然而,亚油酸是液体形式并且容易被氧化。这项研究的目的是使用乙基纤维素作为涂层聚合物制备GSE微胶囊,并配制含有GSE微胶囊的凝胶。方法:采用溶剂蒸发法,以油和聚合物的比例为基础,以1:1、1:2、1:3和1:4的比例混合乙基纤维素,制备GSE微胶囊。所生产的GSE微胶囊的特征在于形态,包封率,粒径和溶胀指数。最好的微胶囊被配制成凝胶剂型,然后进行评估。结果:结果表明,微囊为球形,无孔,包封率为45.81〜93.87%。 F1,F2,F3和F4微胶囊的平均体积直径分别为83.58 nm,129.40 nm,151.15 nm和202.74 nm。微胶囊的溶胀指数在49-73%的范围内。此外,含有2%GSE微胶囊的凝胶表现出良好的外观,粘度为10,800 cps,具有塑性流动性。结论:GSE与乙基纤维素之比为1:4的GSE F4微囊是最佳微囊,包封率为93.87%。掺入凝胶制剂中的GSE微胶囊对于皮肤保湿剂而言将是有趣的化妆品。

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