Sarcopenia and its Association with Geriatric Syndromes and Quality of Life in Older Indian Outpatients - A Cross- sectional Pilot Obesrvation Study

摘要

Background: Despite the huge clinical impact of sarcopenia, there is very little to no data from Indiansubcontinent regarding sarcopenia in older adults. We conducted this study to assess the frequency ofsarcopenia in Indian older outpatients and its characteristics and associations with various geriatricsyndromes and quality of life in Indian older adults. Methods: 100 participants above the age of 65 yearswere recruited from the outpatient department of Geriatric Medicine of a tertiary care hospital in India.Muscle mass, muscle strength and physical performance was measured by DXA scan (Dual Energy X-rayAbsorptiometry), hand-held dynamometer and 4 m gait speed respectively. Sarcopenia was identifed using anAsian working group for sarcopenia (AWGS) criteria. Many geriatric syndromes such as osteoporosis,dementia, depression and malnutrition were assessed using DXA scan (Dual Energy X-ray Absorptiometry),HMSE (Hindi Mental State Questionnaire), GDS-5 (Geriatric Depression scale - 5 item questionnaire) andMNA (Mini Nutritional Assessment) respectively. Quality of life was assessed using the OPQOL-briefquestionnaire. Results: The prevalence of sarcopenia in our study population was 53% (49.3% in males, 61.3%in females). Hypothyroidism, neurological disease and osteoporosis were the only comorbidities found to bepositively associated with sarcopenia. Among geriatric syndromes, nutrition and cognition were negativelyassociated with sarcopenia. Sarcopeniawas also negatively related to the quality of life. Multivariate stepwiselogistic regression analysis showed that osteoporosis (OR: 5.43; 95% CI: 1.57-18.81; p-value: 0.01) wassignificantly associated with sarcopenia.Conclusion: Sarcopenia was common among Indian olderoutpatients with increased risk of geriatric syndromes and poor quality of life, therefore, a regular sarcopeniaassessment may be considered in elderly patients.