Expression of soluble and membrane-bound programmed death protein 1 in psoriasis vulgaris patients: a case-controlled study

摘要

and membrane-bound PD1 levels in psoriatic patients, and to correlate them with disease severity. Patients and methods Twenty-one psoriatic patients and 20 age-matched and sex-matched controls were included. Full clinical examination was done and tissue and blood levels of PD1 were measured by enzyme-linked immunosorbent assay. Results Levels of sPD1 were significantly lower in patients than in controls (P0.001). Regarding the level of tissue PD1, it was lower in psoriatic skin biopsies (0.32?±0.22) than in controls (0.54?±0.08); however, this difference was not statistically significant (P=0.89). A statistically significant positive correlation was found between tissue and sPD1 levels (P=0.02, r=0.5), and a significant negative correlation with the extent of the disease (P=0.024, r=a??0.5). Conclusion Psoriatic patients have significantly lower sPD1 level. PD1 might play an important role in the pathogenesis of psoriasis vulgaris....