Rate of acceptance of deceased-donor kidneys decreases with donor age despite the growing number of aged transplant candidates on the waiting list. In the Eurotransplant Senior Program, HLA-unmatched kidneys from deceased donors aged a‰￥65 yr are transplanted regionally into recipients aged a‰￥65 yr. Because we have become more willing to accept kidneys from donors aged a‰￥75 yr than previous years, we performed a retrospective analysis of this subgroup. Kidneys were accepted from donors aged a‰￥75 yr provided a normal creatinine on admission to the hospital, a Cockcroft-Gault creatinine clearance 80 ml/min, and an absence of comorbidities. We compared outcomes of kidneys from donors aged a‰￥75 yr with both younger-donor kidneys transplanted in the Eurotransplant Senior Program and with younger-donor HLA-matched kidneys transplanted into recipients a‰￥60 yr. There were no differences in 5-yr graft and patient survival or rate of delayed graft function between groups. Graft function, measured by creatinine and creatinine clearance, differed without pattern at only three of 12 time points during 5 yr of follow-up. In conclusion, our data suggest that kidneys from deceased donors aged a‰￥75 yr can be transplanted safely into recipients aged a‰￥65 yr if similar donor criteria and local allocation practices are used.
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机译：尽管等待名单上的老年移植候选者越来越多，但捐赠者已故肾脏的接受率却随着捐赠者的年龄而降低。在欧洲移植高级计划中，来自年龄≥65岁的已故捐赠者的HLA无与伦比的肾脏被局部移植到年龄≥65岁的受者中。由于我们比前几年更愿意接受年龄≥75岁的捐赠者的肾脏，因此我们对该子组进行了回顾性分析。从入院时年龄≥75岁的供体中接受肾脏，条件是肌酐在入院时正常，Cockcroft-Gault肌酐清除率> 80 ml / min，且无合并症。我们比较了年龄≥75岁的供者的肾脏结局，欧洲移植高级计划中移植的年轻供体肾脏和移植了受体的年轻供体HLA匹配肾脏（≥60年）。各组之间的5年移植物和患者生存率或移植物功能延迟率无差异。通过肌酐和肌酐清除率测量的移植功能在随访的5年中仅12个时间点中的3个时间点没有变化。总之，我们的数据表明，如果使用类似的捐赠者标准和本地分配方法，则年龄≥75岁的已故供者的肾脏可以安全地移植到年龄≥65岁的受者中。
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