Serum Phosphate: A Novel Cardiovascular Risk Factor Even in Nonrenal Patients Relation between Serum Phosphate Level and Cardiovascular Event Rate in People with Coronary Disease. Circulation 112: 2627-2633, 2005

摘要

It has been known for decades that hyperphosphatemia is a feature of ESRD that may cause secondary hyperparathyroidism and soft tissue calcification (1), including vascular calcification (2). The latter comprises mainly calcification of intimal plaques (3) and of the media (4,5) of central arteries (M??nckeberg sclerosis), less frequently calcification of muscular arteries (the only type of vascular calcification that potentially disappears after reversal of hyperparathyroidism [6]) and calcific uremic arteriolopathy (calciphylaxis) (7,8).