A retrospective study on potential drug interactions: A single center experience

摘要

Background In this study, it is aimed to explain the type and frequency of potential drug-drug interactions (pDDI) in patients a Medical oncology service. Methods This study retrospective descriptive design. pDDIs were identified using the checker programme (Medscape ? ). Interactions were classified according to their clinical relevance as minor, moderate and major as appropriate. Results The prevalence of pDDIs was 71.3% and median age was 61 years-old (interquartile range 54–68) and female to male ratio was 116/211. The median number of drugs per patient was 8 (interquartile range 5–10). A total of 1102 pDDIs of 327 hospitalized cancer patients were identified. Of those, 16.7% were major and 61.8% moderate, respectively. Concomitant use of opioids was the most common interaction in our study. Conclusions Drug interactions were common in hospitalized cancer patients. In order to prevent potential hazardous effect of pDDI, awareness of the physicians should be increased about this issue.