Demographic characteristics of patients who recovered or worsened after intravenous thrombolysis within 24 hours of acute ischemic stroke

摘要

Objective: The aim of this study was to evaluate the demographics of patients who experienced recovery or worsening afterreceiving intravenous thrombolytic treatment within 24 hours of the onset of acute ischemic stroke (AIS).Methods: This retrospective study included patients with AIS who were admitted to emergency units within 4.5 hours of AISbetween January 2012 and December 2015. Recovery was defined as a decrease of ≥4 points in the National Institutes of HealthStroke Scale (NIHSS) score within 24 hours (group I), and worsening was defined as an increase of ≥4 points in NIHSS score within24 hours compared with admission (group II).Results: The study included a total of 86 patients comprising 55.8% males, with a mean (±SD) age of 61.1 (±13.1) years. Themean patient age was similar in both sexes. Of the total 86 patients, 80.2% experienced recovery within 24 hours (group I) andsymptoms worsened in 19.8% (group II). No significant sex or age difference was determined in terms of recovery. Patients receivingthrombolysis within 1-3 hours had a higher recovery ratio compared with patients who received treatment within 3-4.5hours. Patients without diabetes mellitus had a better recovery ratio compared with those with diabetes mellitus.Conclusion: A relatively high recovery rate was determined at 24 hours after thrombolysis in patients with AIS. Demographiccharacteristics were not determined to be contributing factors to this outcome, but the time to thrombolytic treatment andhaving diabetes mellitus were observed to be more significant predictors of patient recovery.