The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study

摘要

Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversibledestruction of nephrons, mainly due to uncontrolled diabetes mellitus and high bloodpressure. Ghrelin is a peptide hormone which could play a substantial role in hungersensation, may increase body fat percentage and might adjust the long-term body weightand is mostly secreted in the stomach.Objectives: This study aimed to evaluate the relationship between ghrelin levels and variousbiochemical and demographic indices in a group of non-diabetic hemodialysis patients.Patients and Methods: Around 39 non-diabetic patients undergoing hemodialysis in Hajarhospital at Shahrekord city were enrolled.Results: The mean age of patients was 57.10 ± 20.20 years. Their mean weight was 56.65±16.25 kg. Their hemoglobin level mean was 10.43 ± 1.84 g/dL. The serum ghrelin levelhad a positive but not significant correlation with the age, dialysis quality, dosage, calciumlevel, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in thesepatients.Conclusions: More studies in this subject of hemodialysis patients to define the exact role ofghrelin in hemodialysis patients are recommended.