Selectins, Activated Leukocyte Cell Adhesion Molecule, and Platelet Endothelial Cell Adhesion Molecule-1 Tissue Levels in Patients With Low- and High-grade Gliomas

摘要

Ground :?Adhesion molecules play an important role(s) in inflammation, tumor cell progression and invasion. Here we investigated tissue levels of selectins (E-, L-, and P-selectins), activated leukocyte cell adhesion molecules (ALCAM), and platelet endothelial cell adhesion molecules-1 (PECAM-1) in a series of patients with glial tumors and controls.? Methods :?A total of 39 patients, 19 with low-grade gliomas and 20 with high-grade gliomas, and 15 deceased controls who underwent autopsy after trauma were included. Adhesion molecules were measured using enzyme-linked immunosorbent assay and the results were analyzed.? Results :?Statistically significant differences were found between the patients and controls regarding every molecule (p<0.05). Furthermore, significantly higher levels were found in patients with high-grade gliomas compared with those with low-grade gliomas.? Conclusion :?These results suggest that adhesion molecules may have a role in glioma formation and targeted therapies could help in the treatment of these devastating brain tumors.