Phytochemicals, antioxidant properties and anticancer investigations of the different parts of several gingers species (Boesenbergia rotunda, Boesenbergia pulchella var attenuata and Boesenbergia armeniaca)

摘要

Extracts (methanol) of the leaves, stem and rhizome of?Boesenbergia specieswere studied for their phytochemical constituents, total phenolics and flavonoid contents, antioxidant as well as anticancer properties.?The plants revealed the presence of polyphenols such as quercetin, kaempferol, rutin, naringin, hesperidin, caffeic acid, p-coumaric acid, ferulic acid, sinapic acid, chlorogenic acid, gallic acid, luteolin and diosmin by using High Performance Liquid Chromatographic (HPLC). It was indicated with significant composition of hesperidin and naringin in?B. pulchella?var?attenuata?(leaves and stem); quercetin and kaempferol in?B. rotunda; luteolin in?B. armeniaca.?The results of antioxidant assessments conducted were similar to the trend of total phenolic and flavonoid contents:?B. pulchella?var?attenuata>?B. rotunda>?B. armeniaca. In the cytotoxicity assay,?B. rotunda?showed the most prominent and promising result as anticancer medicinal plant. It showed positive antiproliferative effect against five cancer cell lines: ovarian (CaOV3), breast (MDA-MB-231 and MCF-7), cervical (HeLa) and colon (HT-29) cancer cell lines with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay conducted. In addition, the rhizome of?B. pulchella?var?attenuata?and?B. armeniaca?shown positive result in cytotoxicity assay tested against breast cancer (MCF-7).?Thus, theBoesenbergia?species investigated would be a promising anticancer remedy for breast cancer.