Relationship Between Hyperhomocysteinemia and Oxidative Stress with Severity of Atherosclerotic Lesion

摘要

The aim of this study was to evaluate correlation between homocysteinemia and oxidative stress with severity of atherosclerotic lesion. We determined the concentration of total homocysteine in serum samples of subjects. The study group consisted of 88 selected patients with CAD, 52 male and 36 females, aged 39-85 (mean 48.65±3.81) years. The control group consisted of 39 normal volunteers, did not coronary artery disease, some sort of systemic screening, such as stress testing was done, 15 male and 24 females, age 38-73 (mean 42.73±0.79) years. The laboratory data of this group were used as a reference. The measurement of serum total homocysteine was performed using ELISA method. The mean serum total homocysteine level was 18.56±2.97 μM L^-1 for females and 17.34±2.26 μM L^-1 for males controls. The mean of total homocysteine level was 20.38±2.86 μM L^-1 for females patients and 22.25 ±2.44 μM L^-1 for males patients, (p-1 for females and 1.43±0.15 mM L^-1 for males controls. The mean level of total antioxidant was 1.34±0.12 mM L^-1 for females patients and 1.32±0.22 mM L^-1 for males patients, (p<0.05). There were no statistically significant differences between levels of serum total homocysteine and total antioxidant in patients and control group. Also, there were no correlation between extension of atherosclerotic lesions and high serum total homocysteine. Results have shown that hyperhomocysteinemia has no important role in progress of atherosclerotic lesions.