Immunoglobulin Expressions in Patients with Homozygous Sickle Cell Disease

摘要

Aim: The serum immunoglobulin (IgA, IgG, IgM) levels of sickle cell patients attending General Hospital Owerri, Nigeria were evaluated to determine whether or not the serum levels of these immunoglobulins were normal. Materials and Methods: One hundred confirmed sickle cell patients (HbSS), and thirty sickle cell patients in crisis age 5–30 years were selected. One hundred normal subjects (HbAA) age 5–30 years were us ed as c ontro l. Re sults : Th e le vels of immunoglobulins (IgA and IgG) were significantly increased in sickle cell anaemia (p0.05), except immunoglobulin M, when compared with the control (HbAA). However, the levels of immunoglobulins (IgA and IgG) were significantly increased in sickle cell crisis compared with sickle disease in steady state. Conclusion: The result suggests that alteration in immune response is associated with Sickle cell disease.