Study of Insulin Resistance and Dyslipidemia in Psoriasis Patients in a Tertiary Care Hospital, South India

摘要

Background: Psoriasis is a chronic immune mediated in.ammatory skin disease with a prevalence of 1–3% in the general population. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Aim & Objectives: To investigate the metabolic state in psoriatic patients in order to clarify the association of psoriasis with insulin resistance and dyslipidemia. Material and Methods: The study included 52 psoriasis patients who attended the Outpatient Department of Dermatology at Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India. The cases were divided into mild (n=28) and severe (n=24) category based on the Psoriasis Area and Severity Index (PASI) score. Fifty healthy controls were also included in the study. Fasting blood glucose, fasting insulin, insulin resistance by Homeostasis Model Assessment (HOMA-IR) method and lipid pro.le were measured in both cases and controls. Results: The fasting insulin levels and insulin resistance measured by HOMA-IR method were signi.cantly (P0.05) higher in mild and severe psoriasis cases when compared to healthy controls. Total Cholesterol, triacyl glycerol, LDL- Cholesterol levels were signi.cantly (P0.05) higher in mild and severe psoriasis cases in comparison with controls. HDL-Cholesterol levels were signi.cantly (P0.05) lower in both mild and severe cases when compared to controls. Conclusion: Our .ndings in this study showed that psoriasis is associated with components of metabolic syndrome like insulin resistance and atherogenic dyslipidemia which are considered to be predisposing factors for diabetes mellitus and cardiovascular diseases. The early detection of insulin resistance and dyslipidemia in psoriasis patients could help them reduce the risk of development of diabetes mellitus and cardiovascular diseases by modifying life style and dietary habits.