Age-specific Mycoplasma pneumoniae pneumonia-associated myocardial damage in children

摘要

Objective To measure Mycoplasma pneumoniae pneumonia (MPP)-associated myocardial damage in different age groups of children with pneumonia. Methods Children aged 0–14 years with pneumonia and myocardial damage (serum creatine kinase isoenzyme-MB [CK-MB] concentration >25?U/l) were enrolled in the study. The children were classified as Mycoplasma pneumoniae immunoglobulin M positive (M. pneumoniae IgM+) or negative (M. pneumoniae IgM?) based on a serological test. Children were stratified into four age groups in order to analyse age-specific MPP-associated myocardial damage. Results The incidence of fever was significantly higher in children who were M. pneumoniae IgM+ compared with M. pneumoniae IgM? children. The median serum CK-MB concentration was significantly higher in children who were M. pneumoniae IgM+ compared with those who were M. pneumoniae IgM?. Children who were M. pneumoniae IgM+ in the 13–36 months and 72 months–14 years age groups had significantly higher median serum CK-MB concentrations than those who were M. pneumoniae IgM? in the same age group. Conclusions M. pneumoniae infection was associated with greater myocardial damage in children aged 13–36 months and 72 months–14 years. This suggests age-specific immune responses to M. pneumoniae.