Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM

摘要

Objective: To study the effect of continuous subcutaneous insulin pump infusion on glucolipidmetabolism as well as inflammation and oxidative stress in placenta of patients with gestationaldiabetes mellitus (GDM). Methods: Patients with GDM who received insulin therapy betweenMarch 2013 and May 2016 were selected as the research subjects and randomly divided intomultiple subcutaneous insulin injection (MSII) group and continuous subcutaneous insulinpump infusion (CSII) group. Before and after treatment, serum glucolipid metabolism as wellas inflammation and oxidative stress inexes in placenta were determined respectively. Results:2 weeks and 4 weeks after treatment, FBG, 1hPBG, 2hPBG, Chemerin, Vaspin and Visfatinlevels of both groups of patients were significantly lower than those before treatment and FBG,1hPBG, 2hPBG, Chemerin, Vaspin and Visfatin levels of CSII group were significantly lowerthan those of MSII group; after delivery, TNF-α, IL-6, ROS and AGEs levels in placentaof CSII group were significantly lower than those of MSII group. Conclusion: Continuoussubcutaneous insulin infusion can more effectively improve the glucolipid metabolism andinhibit the inflammation and oxidative stress in placenta of patients with GDM than multiplesubcutaneous insulin injection.