Effects of dexmedetomidine on inflammatory response and oxidative stress in laparoscopic hysterectomy patients

摘要

Objective: To investigate the effect of dexmedetomidine on inflammatory response andoxidative stress in patients with laparoscopic total hysterectomy. Methods: Ninety patients withlaparoscopic hysterectomy under general anesthesia were selected in our hospital from January2015 to December 2016, and randomly divided into control group and observation group,Each group of 45 cases. The observation group was given dexmedetomidine, intravenouspump injection, The control group was given the same amount of saline in the same manner,followed by anesthesia induction. The hemodynamics, inflammatory factors and oxidativestress were monitored before anesthesia (T0), 30 min after the end of pneumoperitoneum (T1),after operation (T2) and at the end of 24 h (T3). Results: Compared with T0, T1, T2 and T3,the observation group of patients with MAP and HR levels were no significant difference;T3,the control group MAP and HR levels were not significantly different; T1 and T2, MAP andHR levels in the control group were significantly increased, And significantly higher thanthe observation group; Compared with T0, the levels of CRP, TNF-α and IL-1β in patientswere significantly increased in T1, T2 and T3, but the levels of CRP, TNF-α and IL-1β inthe observation group were significantly lower than those in the control group; Comparedwith T0, both groups of patients with H2O2 and MDA levels were significantly increased, TASlevels were significantly reduced, the difference was statistically significant, However, thelevels of H2O2 and MDA in the observation group were significantly lower than those in thecontrol group, the level of TAS was significantly higher than the control group. Conclusion:Laparoscopic hysterectomy increases the inflammatory response and oxidative stress inpatients, while the use of dexmedetomidine can maintain hemodynamic stability in a certainextent, reduce the inflammatory response and reduce oxidative stress injury; it is worth offurther clinical application.