The correlation of serum sEng and ADMA levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia

摘要

Objective: To study the correlation of serum soluble endoglin (sEng) and asymmetricdimethylarginine (ADMA) levels with placental hypoxia injury and cell apoptosis in patientswith preeclampsia. Methods: 56 patients diagnosed with preeclampsia in our hospital betweenMay 2014 and March 2016 were selected as PE group, healthy subjects giving birth duringthe same period were selected as control group, serum was collected to determine sEng andADMA levels, and the placenta tissue was collected to determine the levels of oxidative stressindexes and cell apoptosis molecules. Results: Serum sEng and ADMA levels of PE groupwere significantly higher than those of control group (P0.05); SOD, GSH-Px, CAT, SVCT1,SVCT2, Survivin and XIAP levels in placenta tissue of PE group were significantly lower thanthose of control group (P0.05) while Beclin1 and LC3-II/LC-I ratio were significantly higherthan those of control group (P0.05); Beclin1 and LC3-II/LC-I ratio in placenta of patientswith high sEng and ADMA levels within PE group were significantly higher than those ofpatients with low sEng and ADMA levels (P0.05) while SOD, GSH-Px, CAT, SVCT1,SVCT2, Survivin and XIAP levels were significantly lower than those of patients with lowsEng and ADMA levels (P0.05). Conclusions: Serum sEng and ADMA levels in patientswith preeclampsia increase significantly and are closely related to the placental hypoxia injuryand cell apoptosis.