The correlation of serum sEng and ADMA levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia

摘要

Objective:To study the correlation of serum soluble endoglin (sEng) and asymmetric dimethylarginine (ADMA) levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia.Methods:56 patients diagnosed with preeclampsia in our hospital between May 2014 and March 2016 were selected as PE group, healthy subjects giving birth during the same period were selected as control group, serum was collected to determine sEng and ADMA levels, and the placenta tissue was collected to determine the levels of oxidative stress indexes and cell apoptosis molecules.Results: Serum sEng and ADMA levels of PE group were significantly higher than those of control group (P<0.05); SOD, GSH-Px, CAT, SVCT1, SVCT2, Survivin and XIAP levels in placenta tissue of PE group were significantly lower than those of control group (P<0.05) while Beclin1 and LC3-II/LC-I ratio were significantly higher than those of control group (P<0.05); Beclin1 and LC3-II/LC-I ratio in placenta of patients with high sEng and ADMA levels within PE group were significantly higher than those of patients with low sEng and ADMA levels (P<0.05) while SOD, GSH-Px, CAT, SVCT1, SVCT2, Survivin and XIAP levels were significantly lower than those of patients with low sEng and ADMA levels (P<0.05).Conclusions:Serum sEng and ADMA levels in patients with preeclampsia increase significantly and are closely related to the placental hypoxia injury and cell apoptosis.