METHOD FOR CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN ADMA-LIKE MODEL OF PREECLAMPSIA

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. Method of correction of placental microcirculation disturbance in ADMA-like model of preeclampsia includes reproduction of preeclampsia model in Wistar rats due daily from 14th to 20th day of pregnancy intraperitoneal introduction of L-nitro-arginine-methyl ether in dose of 25 mg/kg, wherein the simulated pathology is corrected by introducing 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate substance in amount of 260 mg/kg intraperitoneally from 14th to 20th day of pregnancy.;EFFECT: invention provides pronounced correction of placental microcirculation disturbance.;1 cl, 1 ex, 1 tbl