Enhancement maximum slope of increase of magnetic resonance angiography in patients with diabetes lower extremity arterial disease and its correlation with endothelial injury and oxidative stress

摘要

Objective: To study the enhancement maximum slope of increase of magnetic resonanceangiography in patients with diabetes lower extremity arterial disease and its correlation withendothelial injury and oxidative stress. Methods: Patients with diabetes lower extremityarterial disease accepting 3D-CEMRA examination in our hospital between May 2013 andDecember 2015 were selected as the pathology group, and the enhancement maximum slopeof increase was measured; healthy volunteers receiving physical examination in our hospitalduring the same period were selected as control group, and serum levels of endothelialoxidative stress injury-related molecules of two groups of subjects were determined. Results:The enhancement maximum slope of increase of the lesion-side anterior tibial artery, posteriortibial artery, peroneal artery and dorsalis pedis artery of pathology group were significantlylower than those of the unaffected-side; serum CyPA, ERK1, ERK2, Akt, JAK, HO-1 and COcontent of pathology group were significantly higher than those of control group and negativelycorrelated with the enhancement maximum slope of increase of lower extremity while Prdx6,SOD, CAT, GSH-Px, eNOS and NO content were significantly lower than those of controlgroup and positively correlated with the enhancement maximum slope of increase of lowerextremity. Conclusion: The enhancement maximum slope of increase of magnetic resonanceangiography significantly reduces in patients with diabetes lower extremity arterial disease andis closely related to oxidative stress-induced endothelial injury as well as eNOS/NO and HO-1/CO system function change.