Effect of adjuvant reduced glutathione therapy on vasoactive molecules and oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage

摘要

Objective: To study the effect of adjuvant reduced glutathione therapy on vasoactive moleculesand oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage.Methods: Patients diagnosed with cirrhosis-induced upper gastrointestinal hemorrhage in No.215 Hospital of Shaanxi Nuclear Industry between June 2015 and March 2017 were selectedas the research subjects, and random number table was used to divide them into the GSHgroup who accepted reduced glutathione combined with conventional therapy and the controlgroup who accepted conventional therapy. Serum levels of liver function indexes, vasoactivemolecules and oxidative stress reaction molecules in two groups of patients were detectedbefore treatment and 3 d after treatment. Results: 3 d after treatment, serum ALT, AST, γ-GT,TBIL, PRA, AT-II, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of both groups of patientswere significantly lower than those before treatment while SOD, GSH-Px and CAT levels weresignificantly high than those before treatment, and serum ALT, AST, γ-GT, TBIL, PRA, ATII,ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of GSH group were significantly lowerthan those of control group while SOD, GSH-Px and CAT levels were significantly higher thanthose of control group. Conclusion: The adjuvant reduced glutathione therapy for cirrhosisinducedupper gastrointestinal hemorrhage can improve the liver function, regulate thesecretion of vasoactive molecules and reduce the oxidative stress response.