The correlation of deceleration capacity of rate with the cardiac function and micro-inflammatory state in patients with both primary hypertension and type 2 diabetes mellitus

摘要

Objective: To study the correlation of deceleration capacity of rate with the cardiac functionand micro-inflammatory state in patients with both primary hypertension and type 2 diabetesmellitus. Methods: A total of 60 patients with both primary hypertension and type 2 diabetesmellitus who were treated in our hospital between May 2012 and February 2016 were collectedas the observation group, and 50 patients with primary hypertension who were treated in ourhospital during the same period were selected as the control group. According to the median ofdeceleration capacity of rate (DC), the observation group of patients were further divided intohigh DC group and low DC group (n=30). The 24 h dynamic electrocardiogram of the includedpatients were obtained to calculate the DC value; color Doppler diasonograph was used tomeasure the echocardiogram of the two groups, and obtain the left cardiac function indexesand strain rate indexes; enzyme-linked immunosorbent assay (ELISA) was used to detect thecontents of serum pro-inflammatory factors and anti-inflammatory factors. Results: The DCvalue of observation group was lower than that of control group; left cardiac function indexesIVSTd, LVIDd and LVIDs levels of low DC group and high DC group were higher than thoseof control group, strain rate indexes SRs, SRe and Sra levels were lower than those of controlgroup, and serum pro-inflammatory factors CRP, IL-6, IL-18 and PCT contents were higherthan those of control group while anti-inflammatory factors IL-10 and IL-13 contents werelower than those of control group; IVSTd, LVIDd and LVIDs levels of low DC group werehigher than those of high DC group, SRs, SRe and Sra levels were lower than those of high DCgroup, and serum CRP, IL-6, IL-18 and PCT contents were higher than those of high DC groupwhile IL-10 and IL-13 contents were lower than those of high DC group. Conclusion: DCvalue is lower in patients with both primary hypertension and type 2 diabetes mellitus, and canintuitively reflect the cardiac function and systemic micro-inflammatory state.