Objective To study the relationship between Hypertension complicated with Type 2 Diabetes and MTHFR C677Tgene.Methods 317 patients treated were selected in the First Affiliated Hospital of Jiamusi University from November 2017 to March 2018 were included in this study after strict screening according to the inclusion criteria and patients compliance.Meanwhile, 73 people who had physical examination at the same time were selected in the physical examination center for genotype analysis using PCR-HRM, and processing data by statistical software.Results The frequency of T alleles was significantly higher in the hypertension group, type 2 diabetes group and hypertension complicated with type 2 diabetes group than in the healthy group, and the difference was statistically significant (61.06％vs.41.78％, 61.39％vs.41.78％, 53.88％vs.41.78％, Prange=0.0003-0.03).TT genotype frequency was significantly higher in hypertensive group and type 2 diabetes group than in healthy group, with statistically significant differences (38.94％ vs.13.70％, 34.65％ vs.13.70％, P=0.0007).Conclusion MTHFR 677 Tgene may be associated with hypertension disease and type 2 diabetes, and the risk of hypertension complicated with type 2 diabetes may be unrelated to the MTHFR 677 Tgene, which needs further discussion in the future.%目的 明确原发性高血压并发2型糖尿病与MTHFR C677T基因的关系.方法 选取佳木斯大学附属第一医院从2017年11月到2018年3月就诊的患者按照入组标准及患者的依从性严格筛选后, 共纳入本实验研究317人, 同时选取同期体检人群73人.运用聚合酶链式反应-高分辨溶解曲线进行基因型检测并采用统计学软件处理数据.结果 高血压组、2型糖尿病组、高血压并发2型糖尿病组T等位基因频率显著高于健康组, 且差异有统计学意义 (61.06％vs.41.78％, 61.39％vs.41.78％, 53.88％vs.41.78％, Prangge=0.0003-0.03);高血压组、2型糖尿病组TT基因型频率明显高于对照组, 差异有统计学意义 (38.94％vs.13.70％, 34.65％vs.13.70％, P=0.0007) .结论MTHFR 677T基因可能与罹患高血压疾病、2型糖尿病有关, 高血压并发2型糖尿病的风险可能与MTHFR 677T基因无关, 未来需进一步探讨.
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