Effects of laparoscopic and open surgery on serum tumor markers, coagulation function and immune function in patients with early endometrial cancer

摘要

Objective: To investigate the effects of laparoscopic surgery and open surgery on serum tumormarkers, coagulation function and immune function in patients with early endometrial cancer.Methods: The clinical data of 82 cases of early endometrial carcinoma were retrospectivelyanalyzed, and they were divided into control group (n=40) and observation group (n=42)according to the treatment plan. Patients in the control group were treated with open surgery,and the observation group received laparoscopic treatment. The levels of serum tumor markers,coagulation function and immune function indexes of the two groups were compared betweenbefore operation and 1 d after operation. Results: The levels of serum CA-125, HE4, PT,APTT, FIB, CD3+, CD4+, CD8+ and CD4+/CD8+in the two groups before treatment werenot significantly different. After treatment, the levels of CA-125, HE4, PT, APTT, CD3+,CD4+and CD4+/CD8+ in the two groups were significantly lower than those before treatmentin the same group, and the levels of CA-125, HE4, PT and APTT in the observation groupwere significantly lower than those in the control group, the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly higher than those of the control group;After treatment, the levels of FIB in the two groups were significantly higher than that beforetreatment, and the level of observation group was significantly higher than that of the controlgroup. Conclusion: Compared with open surgery for early endometrial cancer, laparoscopicsurgery can effectively reduce the level of serum tumor markers and the inhibition of immunefunction, however, it has great influence on coagulation function, and effective measuresshould be taken to prevent the formation of thrombotic diseases.