Effect of rabdosia rubescens combined with new assistant chemotherapy on serum CA199, CEA, CA15-3 and T lymphocyte subsets in patients with breast cancer

摘要

Objective: To study the effects of Rabdosia rubescens combined with neoadjuvantchemotherapy on serum CA199, CEA, CA15-3 levels and T lymphocyte subsets in patientswith breast cancer. Methods: A total of 70 patients with breast cancer in our hospital wereenrolled as the subjects of this study. The subjects were divided into control group (n=35) andtreatment group (n=35) randomly. Patients in the control group were treated with new assistantchemotherapy, while those who were in the treatment group were treated with rabdosiarubescens combined with new assistant chemotherapy. The two groups of patients were treatedfor 3 periods. The serum CA199, CEA, CA15-3 levels and peripheral blood CD4+, CD8+,CD4+/CD8+ cells of the two groups before and after treatment were compared. Results: Therewere no significantly differences among the serum CA199, CEA, CA15-3 levels and peripheralblood CD4+, CD8+, CD4+/CD8+ cells of the two groups before treatment. The serum CA199,CEA and CA15-3 levels of the two groups after treatment were significantly lower than thosebefore treatment, besides, the serum CA199, CEA and CA15-3 levels of the treatment groupwere significantly lower than those of the control group. The peripheral blood CD4+, CD4+/CD8+ cells of the control group after treatment were significantly lower than before treatment,and the peripheral blood CD4+, CD4+/CD8+ cells of the treatment group after treatmentwere significantly higher than those of the control group. Conclusion: Rabdosia rubescenscombined with new assistant chemotherapycan can significantly reduce the serum CA199,CEA and CA15-3 levels, and improve peripheral blood CD4+, CD8+, CD4+/CD8+ levels ofpatients with breast cancer. It is worthy of clinical application.