Comparison of pain media and inflammatory factors after percutaneous transforaminal endoscopic discectomy and traditional fenestration operation treatment of protrusion of lumbar intervertebral disc

摘要

Objective: To compare the differences in pain mediators and inflammatory factors afterpercutaneous transforaminal endoscopic discectomy and traditional fenestration operationtreatment of protrusion of lumbar intervertebral disc. Methods: 80 patients with protrusionof lumbar intervertebral disc treated in our hospital between March 2013 and December2015 were collected and divided into observation group and control group (n=40) accordingto randomized parallel contrast. Control group received traditional fenestration operationand observation group received percutaneous transforaminal endoscopic discectomy.Before operation and 1 week after operation, fluorescence spectrophotometry was used todetermine serum pain medium levels; ELISA was used to determine pro-inflammatory factorand anti-inflammatory factor levels. Results: Before operation, differences in serum painmedium and inflammatory factor levels were not statistically significant between two groups(P0.05). 1 week after operation, serum pain media norepinephrine (NE), dopamine (DA),5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2) and substance P (SP) levels as well aspro-inflammatory factors interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18)and tumor necrosis factor alpha (TNF-α) levels of observation group were lower than those ofcontrol group (P0.05) while serum anti-inflammatory factors interleukin-4 (IL-4), interleukin10 (IL-10), soluble tumor necrosis factor receptor I (sTNF-RI) levels were higher than thoseof control group (P0.05). Conclusions: Percutaneous transforaminal endoscopic discectomycan effectively treat protrusion of lumbar intervertebral disc and is more advantageous inalleviating patients’ perception of pain and reducing inflammation.