Molecular mechanisms for Haikunshenxi capsule combined with conventional western medicine to improve renal function in patients with diabetic nephropathy

摘要

Objective: To study the molecular mechanisms for Haikunshenxi capsule combined withconventional western medicine to improve renal function in patients with diabetic nephropathy.Methods: A total of 146 patients with diabetic nephropathy treated in our hospital betweenMay 2013 and December 2015 were selected as the research subjects and randomly dividedinto two groups, 73 in each group. The observation group of patients received Haikunshenxicapsule combined with conventional western medicine treatment, and the control groupof patients received routine western medicine treatment. 4 weeks after treatment, the renalbiochemical indexes, renal fibrosis indexes and oxidative stress indexes in blood and urinewere determined. Results: 4 weeks after treatment, serum creatinine (Scr), blood urea nitrogen(BUN), cystatin C (CysC), transforming growth factor-β1 (TGF-β1), connective tissue growthfactor (CTGF), fibronectin (FN), laminin (LN) and type IV collagen (IV-Col) content in bloodof observation group were significantly lower than those of control group (P0.05), and 24h urine protein, urine albumin/creatinine ratio (UACR) level as well as alkaline phosphatase(ALP), γ-glutamyl transpeptidase (GGT), malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) content in urine of observation group were significantly lowerthan those of control group (P0.05) while superoxide dismutase (SOD) and glutathioneperoxidase (GSH-Px) content in urine were significantly higher than those of control group(P0.05). Conclusions: Haikunshenxi capsule combined with conventional western medicinecan improve renal function in patients with diabetic nephropathy through the molecularmechanisms of inhibiting renal fibrosis and reducing oxidative stress.