Molecular mechanisms for Haikunshenxi capsule combined with conventional western medicine to improve renal function in patients with diabetic nephropathy

摘要

Objective:To study the molecular mechanisms for Haikunshenxi capsule combined with conventional western medicine to improve renal function in patients with diabetic nephropathy. Methods: A total of 146 patients with diabetic nephropathy treated in our hospital between May 2013 and December 2015 were selected as the research subjects and randomly divided into two groups, 73 in each group. The observation group of patients received Haikunshenxi capsule combined with conventional western medicine treatment, and the control group of patients received routine western medicine treatment. 4 weeks after treatment, the renal biochemical indexes, renal fibrosis indexes and oxidative stress indexes in blood and urine were determined.Results:4 weeks after treatment, serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (CysC), transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), fibronectin (FN), laminin (LN) and type IV collagen (IV-Col) content in blood of observation group were significantly lower than those of control group (P<0.05), and 24 h urine protein, urine albumin/creatinine ratio (UACR) level as well as alkaline phosphatase (ALP),γ-glutamyl transpeptidase (GGT), malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) content in urine of observation group were significantly lower than those of control group (P<0.05) while superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) content in urine were significantly higher than those of control group (P<0.05).Conclusions:Haikunshenxi capsule combined with conventional western medicine can improve renal function in patients with diabetic nephropathy through the molecular mechanisms of inhibiting renal fibrosis and reducing oxidative stress.