SYSTEMIC INSULIN-LIKE GROWTH FACTOR-1 THERAPY REDUCES DIABETIC PERIPHERAL NEUROPATHY AND IMPROVES RENAL FUNCTION IN DIABETIC NEPHROPATHY

摘要

The present invention provides methods of treatment of patients suffering from the complication of blood sugar disorders diabetic peripheral neuropathy and diabetic nephropathy by administration of IGF-1 via protein therapy or gene therapy It relates to methods of treating an individual having a diabetic disorder or a hyperglycemic disorder, comppsing administepng to the individual an effective amount of a DNA vector expressing IGF-1Eb or IGF-1Ec in vivo or an effective amount of the IGF-1Eb or IGF-1Ec protein in the early hyperalgesia stage or in patient that have advanced to the hyposensitivity stage