Effect of fasudil combined with conventional therapy on nerve and blood coagulation function as well as Hcy metabolism in patients with acute cerebral infarction

摘要

Objective: To analyze the effect of fasudil combined with conventional therapy on nerve andblood coagulation function as well as Hcy metabolism in patients with acute cerebral infarction.Methods: 80 patients with acute cerebral infarction treated in our hospital between January2013 and January 2013 were selected as the research subjects and divided into observationgroup (n = 40) and control group (n = 40) according to the random number table. Controlgroup received conventional therapy and observation group received fasudil combined withconventional therapy. After 14 d of treatment, the levels of cerebral blood perfusion parameters,nerve function indexes, platelet function indexes and homocysteine (Hcy) of two groupsof patients were determined. Results: After 14 d of treatment, middle cerebral artery andbasilar artery peak systolic flow velocity (Vs), low diastolic flow velocity (Vd) and mean flowvelocity (Vm) levels of observation group were higher than those of control group (P0.05);serum nerve function indexes brain-derived neurotrophic factor (BDNF) and nerve growthfactor (NGF) content were higher than those of control group (P0.05) while phosphatidic acid(PA), neuron-specific enolase (NSE), S100β protein (S100β), and substantia nigra divalentmetal transporter 1 (DMT1) content were lower than those of control group (P0.05); serumplatelet function indexes platelet activation-dependent granule membrane protein-140 (GMP-140), fibrinogen receptor-1 (PAC-1), platelet activating factor (PAF) and platelet-derivedgrowth factor BB (PDGF-BB) content were lower than those of control group (P0.05); serumHcy content was lower than that of control group (P0.05). Conclusions: Fasudil combinedwith conventional therapy can optimize the nerve function and blood coagulation function inpatients with acute cerebral infarction, and also plays a positive role in reducing Hcy levels.