Effects of butyphthalide combined with routine anticoagulant and antioxidant therapy on nerve function, angiogenesis and free radical generation in patients with acute cerebral infarction

摘要

Objective: To investigate the effects of butyphthalide combined with routine anticoagulant and antioxidant therapy on the nerve function, angiogenesis and free radical generation in patients with acute cerebral infarction. Methods: A total of 142 patients with acute cerebral infarction who were treated in this hospital between August 2014 and January 2017 were collected as research subjects and divided into control group (n=71) and butyphthalide group (n=71) by random number table method. Control group received routine anticoagulant and antioxidant therapy, and butyphthalide group received butyphthalide combined with routine anticoagulant and antioxidant therapy. The differences in serum nerve function indexes, angiogenesis indexes and free radical generation-related indexes were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in serum levels of nerve function indexes, angiogenesis indexes and free radical generation-related indexes between the two groups of patients. After treatment, serum nerve function index IGF-1 level of butyphthalide group was higher than that of control group whereas copeptin, PAO and H-FABP contents were lower than those of control group; serum angiogenesis indexes VEGF, MMP-2 and MMP-9 contents were higher than those of control group; serum contents of free radical generation-related indexes ROS and MDA were lower than those of control group. Conclusions: Butyphthalide combined with routine anticoagulant and antioxidant therapy can effectively optimize the nerve function, promote the cerebral angiogenesis and inhibit the free radical generation in patients with acute cerebral infarction.