Objective To investigate the effect of butylphthalide on the neurological function and the levels of (S-100B),homocysteine(Hcy),angiopoietin-1(ANG-1)in patients with acute cerebral infarction(ACI). Methods A total of 84 patients with ACI were selected from January 2016 to September 2017 in Henan Rongjun Hospital. The patients were divided into observation group and control group according to the treatment method,with 42 cases in each group. The patients in the two groups were treated with antithrombosis,blood sugar and blood pressure control,nutritional support,infection prevention and other conventional treatment measures. On the basis of routine treatment,the patients in the observation group were treated with butylphthalide injection 100 mL by intravenously guttae,twice a day for two weeks. The neurologic impairment of the patients in the two groups was assessed by the National Institutes of Health Stroke Scale(NIHSS)before and after treatment. The mental state and cognitive function of the patients in the two groups were scored by the mini-mental state examination(MMSE). The levels of serum S100B and ANG-1 were detected by Enzyme-linked immunosorbent assay. The level of Hcy was detected by AU480 automatic biochemical analyzer. The curative effect was evaluated after two weeks of treatment,and the adverse reac-tions of the patients were observed. Results There was no significant difference in the scores of NIHSS and MMSE between the two groups before treatment(P > 0. 05). The NIHSS score after treatment was significantly lower than that before treatment, and the MMSE score was significantly higher than that before treatment in the two groups(P < 0. 05). The NIHSS score in the observation group was significantly lower than that in the control group,and the MMSE score was significantly higher than that in the control group after treatment(P < 0. 05). There was no significant difference in serum S100B,Hcy and ANG-1 levels be-tween the two groups before treatment(P > 0. 05). The levels of serum S100B and Hcy after treatment were significantly lower than those before treatment,and the ANG-1 level was significantly higher than that before treatment in the tao groups(P <0. 05). The levels of serum S100B and Hcy in the observation group were significantly lower than those in the control group, and the ANG-1 level was significantly higher than that in the control group after treatment(P < 0. 05). The total effective rate in the observation group and the control group was 90. 48％(38 / 42)and 71. 43％(30 / 42)respectively,the total effective rate in the observation group was significantly higher than that in the control group(χ2 = 4. 659,P < 0. 05). The incidence of ad-verse reactions in the observation group and the control group was 11. 90％(5 / 42)and 9. 52％(4 / 42)respectively,there was no significant difference in the incidence of adverse reactions between the two groups(χ2 = 0. 092,P > 0. 05). Conclusion Butylphthalide can effectively regulate the levels of serum S100B,Hcy and ANG- 1,and improve the neurological function of patients with ACI.%目的 探讨丁苯酞对急性脑梗死(ACI)患者的神经功能及血清S100B、同型半胱氨酸(Hcy)及血管生成素-1(ANG-1)水平的影响.方法 选择2016年1月至2017年9月河南省荣军医院收治的ACI患者84例,根据治疗方法分为观察组和对照组,每组42例.2组患者均给予抗血栓、控制血糖和血压、营养支持、预防感染等常规治疗措施,观察组患者在常规治疗基础上给予丁苯酞注射液100 mL,静脉滴注,每日2次,连续治疗2周.分别于治疗前后应用美国国立卫生研究院卒中量表(NIHSS)对2组患者的神经功能缺损进行评分,应用简易精神状态评价量表(MMSE)对2组患者的智力状态及认知功能进行评分,采用酶联免疫吸附试验检测血清S100B、ANG-1水平,采用AU480全自动生物化学分析仪检测Hcy水平;治疗2周后进行疗效评价,并观察患者不良反应发生情况.结果 2组患者治疗前NIHSS、MMSE评分比较差异均无统计学意义(P>0.05);2组患者治疗后NIHSS评分显著低于治疗前,MMSE评分显著高于治疗前(P<0.05);治疗后观察组患者NIHSS评分显著低于对照组,MMSE评分显著高于对照组(P<0.05).2组患者治疗前血清S100B、Hcy及ANG-1水平比较差异均无统计学意义(P>0.05);2组患者治疗后血清S100B、Hcy水平显著低于治疗前,ANG-1水平显著高于治疗前(P<0.05);治疗后观察组患者血清S100B、Hcy水平显著低于对照组,ANG-1水平显著高于对照组(P<0.05).观察组和对照组患者治疗总有效率分别为90.48％(38/42)、71.43％(30/42),观察组患者治疗总有效率显著高于对照组(χ2=4.659,P<0.05).观察组和对照组患者不良反应发生率分别为11.90％(5/42)、9.52％(4/42),2组患者不良反应发生率比较差异无统计学意义(χ2=0.092,P>0.05).结论 丁苯酞可以有效调节ACI患者血清S100B、Hcy和ANG-1水平,改善患者的神经功能.
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