Correlation of contrast-enhanced ultrasonography time-intensity curve parameters of bladder cancer with the invasive growth of cancer cells and the angiogenesis in the lesion

摘要

Objective: To study the correlation of contrast-enhanced ultrasonography time-intensity curve parameters of bladder cancer with the invasive growth of cancer cells and the angiogenesis in the lesion. Methods: Patients with bladder cancer who underwent surgical resection in Ezhou Central Hospital between March 2015 and April 2017 were selected as the research subjects, they received preoperative contrast-enhanced ultrasonography, the time-intensity curve was drawn, and the parameters AT, PT, WT and PI of bladder cancer tissue and adjacent tissue were calculated; after surgery, the bladder cancer tissue and adjacent tissue were collected to measure the expression of proliferation, invasion and angiogenesis molecules. Results: AT, PT and WT levels in bladder cancer tissue were significantly lower than those in adjacent tissue whereas PI level as well as Rce1, YAP, β-catenin, c-myc, CUGBP1, Annexin-II, uPA, CXCL10, CXCR3, ILK, VEGF, COX2, HIF-1α and NAC1 mRNA expression was significantly higher than those in adjacent tissue; Rce1, YAP, β-catenin, c-myc, CUGBP1, Annexin-II, uPA, CXCL10, CXCR3, ILK, VEGF, COX2, HIF-1α and NAC1 mRNA expression in bladder cancer tissue were negatively correlated with the AT, PT and WT levels, and were positively correlated with the PI level. Conclusion: The change of the contrast-enhanced ultrasonography time-intensity curve parameters of bladder cancer is valuable for evaluating the invasive growth of cancer cells and the angiogenesis in the lesion.