Effects of minocycline combined with periocline on the levels of inflammatory factors, ALP and NO in gingival crevicular fluid of patients with periodontitis

摘要

Objective: To investigate the effect of minocycline combined with periocline on patients with periodontitis, and analyze the effect of inflammatory factors, ALP and NO levels in the gingival sulcus fluid. Methods: A total of 100 cases of patients with periodontitis admitted in our hospital from December 2016 to May 2017, with a total of 128 teeth. They were divided into control group and observation group by the random number method, 64 teeth in each group. Patients in both groups were given conventional supragingival scaling and subgingival curettage therapy. The control group patients were given minocycline ointment in periodontal pockets until overflow, once a week; the observation group was given periocline treatment on the basis of control group. Oral administration 2 capsules each time, 2 times each day. The two groups were both treated for 4 weeks. The general indicators of teeth in both groups were compared. The levels of inflammatory factors, ALP and NO in gingival crevicular fluid of the two groups were detected before and after the treatment. Results: Before treatment, there was no significant difference in the levels of PLI, PD, SBI, AL and TNF-α, CRP, ALP and NO in the gingival crevicular fluid of the both groups. After treatment, the levels of PLI, PD, SBI, AL and TNF-α, CRP, ALP and NO in the gingival crevicular fluid of the two groups were significantly decreased than those before the treatment, and the levels of PLI, PD, SBI, AL and TNF-α, CRP, ALP and NO in gingival crevicular fluid after treatment in the observation group were all significantly lower than that in the control group after treatment, the differences were statistically significant. Conclusion: Minocycline combined with periocline can improve the periodontal condition and gingival crevicular fluid inflammatory state in patients with periodontitis, reduce the activity of ALP and NO. It has the effect of antiseptic and induced osteogenesis and improving the clinical effect.