Clinical study that preoperative intracavitary radiotherapy combined with neoadjuvant chemotherapy promotes apoptosis in IIa and IIb cervical cancer tissue

摘要

Objective: To study the effect of preoperative intracavitary radiotherapy combined withneoadjuvant chemotherapy on apoptosis in IIa and IIb cervical cancer tissue. Methods:Patients with IIa and IIb locally advanced cervical cancer who received preoperative auxiliarytherapy in our hospital between May 2013 and December 2016 were retrospectively analyzedand divided into adjuvant chemotherapy group, intracavitary radiotherapy group and combinedtreatment group according to the different preoperative adjuvant therapies. Cervical cancertissues were collected respectively during biopsy (before treatment) and during surgicalexcision (after treatment) to extract RNA, and then fluorescence quantitative PCR kits wereused to determine the expression of pro-apoptosis genes, anti-apoptosis genes and invasiongenes. Results: After treatment, SARI, Rab26, FHIT and eIF4E3 expression in cervical cancerlesions of three groups were significantly higher than those before treatment while serumCA125, TSGF and SCC-Ag levels as well as MRP8, MRP14, p38MAPK, ERK1/2 and c-mycexpression were significantly lower than those before treatment, and SARI, Rab26, FHIT andeIF4E3 expression in cervical cancer lesions of combined treatment group were significantlyhigher than those of adjuvant chemotherapy group and intracavitary radiotherapy group whileserum CA125, TSGF and SCC-Ag levels as well as MRP8, MRP14, p38MAPK, ERK1/2and c-myc expression were significantly lower than those of adjuvant chemotherapy groupand intracavitary radiotherapy group. Conclusion: Preoperative intracavitary radiotherapycombined with neoadjuvant chemotherapy can promote apoptosis in IIa and IIb cervical cancertissue.