Changes of serum tumor markers, immunoglobulins, TNF-α and hs-CRP levels in patients with breast cancer and its clinical significance

摘要

Objective: To study the serum tumor markers, immunoglobulin, TNF-α and hs-CRP inbreast cancer in different pathological stages of the concentration, and to analyze the clinicalsignificance of early diagnosis of breast cancer. Methods: A total of 130 patients with breastcancer were divided into stage I, II, III and IV according to clinical pathology. In addition,40 patients with benign breast disease and 35 healthy subjects were selected as benignbreast disease group and control group. Serum tumor markers, immunoglobulins, TNF-αand hs-CRP concentrations were measured and compared of all subjects. Results: Therewere no significant difference in serum tumor markers, immunoglobulin and inflammatoryfactors between the control group and the benign breast cancer group. The level of serumtumor markers in breast cancer group was significantly higher than that in control group andbenign breast cancer group. The levels of serum CA125, CA153 and CEA were graduallyincreased with the severity enhancing from stage I and IV of breast cancer, and he differencewas statistically significant. The level of serum immunoglobulin in breast cancer group wassignificantly higher than that in control group and benign breast cancer group. The levels ofserum IgG and IgM increased gradually severity enhancing from stage I and IV of breastcancer, and the difference was statistically significant. The level of serum TNF-α and hs-CRPin serum of breast cancer group was significantly higher than that of control group and benignbreast cancer group. The serum levels of TNF-α and hs-CRP increased gradually with severityenhancing from stage I and IV of breast cancer, and the difference was statistically significant.Conclusion: The level of serum tumor markers in breast cancer patients is increasing. Humoraland inflammatory responses are activated to varying degrees and increase with the aggregationof disease. They may involve regulating the occurrence and metastasis of breast cancerand regulating the pathophysiological function of patients. Which may be a certain clinicalsignificance for the early diagnosis of breast cancer and disease progression.