Effect of the adaptive intermittent ventilation before radical operation for lung cancer under one-lung ventilation on the non-ventilated lung tissue injury and apoptosis molecule protein expression

摘要

Objective: To study the effect of the adaptive intermittent ventilation before radical operationfor lung cancer under one-lung ventilation on non-ventilated lung tissue injury and apoptosismolecule protein expression. Methods: A total of 288 patients who received radical operationfor lung cancer in the hospital between February 2015 and January 2017 were dividedinto control group and observation group by random number table method, each with 144cases. Control group received routine one-lung ventilation, and observation group receivedpreoperative adaptive intermittent ventilation of non-ventilated lung tissue. The differencesin the levels of inflammatory factors and oxidative stress indexes in serum as well as theapoptosis molecule protein expression in affected-side normal lung tissue were comparedbetween the two groups of patients immediately after intubation and at two-lung ventilation(T0) as well as 10 min before operation ended and at one-lung ventilation (T1). Results: AtT0, the differences in the levels of inflammatory factors and oxidative stress indexes in serumas well as the apoptosis molecule protein expression in affected-side normal lung tissue werenot significantly significant between the two groups of patients; at T1, IL-1β, IL-8, TNF-α,MPO and MDA levels in serum as well as Bax, caspase-2 and caspase-3 protein expressionin normal lung tissue of observation group were lower than those of control group while SODlevel in serum and Bcl-2 protein expression in normal lung tissue were higher than those ofcontrol group. Conclusion: Adaptive intermittent ventilation before radical operation for lungcancer under one-lung ventilation can effectively reduce the non-ventilated lung tissue injuryand inhibit the apoptosis of normal lung cells.