Effect of Dan seven soft capsule adjuvant therapy on serum inflammatory factors, coagulation function and blood rheology indexes in patients with acute hemorrhagic cerebrovascular disease

摘要

Objective: To investigate the effect of Dan seven soft capsule on the treatment of acutehemorrhagic cerebrovascular disease and the influence of serum inflammatory factors,coagulation function and blood rheology indexes. Methods: A total of 112 cases of patientswith acute hemorrhagic cerebrovascular disease, according to the random data table weredivided into the control group (n=57) and observation group (n=55), the patients in the controlgroup received routine treatment combined with edaravone, on the basis of the treatmentof the control group, the observation group was treated with Dan seven soft capsule. Theserum levels of inflammatory factors, coagulation function and blood rheology indexes werecompared between the two groups before and after treatment. Results: Before treatment, therewere no significant difference in the inflammatory factors (hs-CRP, TNF-α and IL-6), bloodcoagulation function (FIB, PT and APTT) and hemorheology (high cut whole blood viscosity,low cut whole blood viscosity and plasma viscosity) levels between the control group andobservation group. Compared with the levels of the same group before treatment, two groupsof hs-CRP, TNF-α, IL-6, FIB, high cut whole blood viscosity, low cut whole blood viscosityand plasma viscosity level after treatment were significantly decreased, and levels in theobservation group were significantly lower than those in the control group; Compared withthe group before treatment, the levels of PT and APTT in the two groups were significantlyincreased, and the observation group was significantly higher than the control group.Conclusion: Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovasculardisease can effectively reduce the level of serum inflammatory factors, improve coagulationfunction and blood rheology index, it has an important clinical value.