Effect of aerobic exercise + relaxation training on the cytokine secretion and endothelial injury in patients with coronary heart disease

摘要

Objective: To study the effect of aerobic exercise + relaxation training on the cytokine secretion and endothelial injury in patients with coronary heart disease. Methods: Patients who were diagnosed with stable angina pectoris in West China Hospital, Sichuan University between August 2014 and October 2017 were enrolled in the study and divided into the exercise training group who accepted aerobic exercise + relaxation training and the normal control group who accepted routine intervention. The levels of cytokines and endothelial injury molecules in serum as well as the expression of oxidative stress molecules in peripheral blood were determined before intervention as well as 56 d and 112 d after intervention. Results: Compared with the corresponding indexes of same group before intervention, serum FGF21, MIF, MIP-1α , SDF-1α, sICAM1, vWF, ET-1, sVCAM-1 and ESM1 levels as well as peripheral blood MPO, NOX2, NOX4, LOX-1 and CX3CR1 expression intensity of both groups of patients were significantly lower 56 d and 112 d after intervention, and serum FGF21, MIF, MIP-1α, SDF-1α, sICAM1, vWF, ET-1, sVCAM-1 and ESM1 levels as well as peripheral blood MPO, NOX2, NOX4, LOX-1 and CX3CR1 expression intensity of exercise training group 56 d and 112 d after intervention were lower than those of normal control group. Conclusion: Aerobic exercise + relaxation training can reduce the secretion of inflammatory cytokines and the degree of endothelial oxidative stress injury in patients with coronary heart disease.