Design Formulation and Evaluation of Soluble Soft Gel Ocular Insert of Ketorolac Tromethamine using Modified Locust Bean Gum

摘要

A major problem in ocular therapeutics is the attainment of optimal drug concentration at the site of action which is compromised mainly due to precorneal loss resulting in only a small fraction of the drug being ocularly absorbed. The effective dose administered may be altered by increasing the retention time of medication into the eye by using ocular inserts for treating various ocular diseases. The aim of the present study was to prepare and evaluate novel Ocular inserts of Ketorolac Tromethamine with polymers like HPMC K4M, PVA, Locust Bean Gum and Modified Locust Bean Gum with Glycerol as plasticizer by film casting method. Nine formulations of ocular inserts based on Comaprision Study On the basis of In vitro release studies & physicochemical parameters, the formulation MOG sustained with maximum cumulative of 97.244% for a period 12 hr and it was found to be better than other formulations; hence MOG 2% was selected as optimized formulation. In vitro drug release kinetic data revealed that all formulation followed near to zero order release kinetics, involving in the all formulation drug release by Super Case-II type of diffusion. Optimized formulation (MOG 12%) passed the test for sterility and in stability studies no change of physiological properties. On the basis of the present study, the ocular inserts of Ketorolac Tromethamine gives promising future for the ophthalmic drug delivery system.