Formulation and Evaluation of fast dissolving films of Granisetron Hydrochloride

摘要

Granisetron hydrochloride is a novel serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. It is well absorbed from the gastrointestinal tract, but its oral bioavailability is low (60%) due to extensive first-pass metabolism which makes it an ideal candidate for rapid release drug delivery system. In the present work we have prepared and evaluated fast dissolving oral films of Granisetron hydrochloride by solvent casting method using different concentrations polymers HPMC, PVA and their combinations. Mannitol was used as a disintegrating agent and Propylene glycol as a plasticizer. The prepared oral films were evaluated for Physical appearance, texture, Weight uniformity, thickness uniformity, percentage moisture absorption, disintegration time, drug content uniformity, folding endurance, tensile strength, in-vitro drug release, and stability studies. In-vitro release rate of Granisetron hydrochloride was studied in phosphate buffer pH 6.8. F1, F5 and F7 showed maximum release rate about 94.95%, 95.98% and 96.29% in 180 seconds respectively, whereas F3 showed 60.98%. Short term stability studies of selected films indicated that there is no significant change with respect to physical appearance, disintegration time, drug content and in-vitro drug release.