COMPARISION OF LOCAL ANAESTHETIC POTENTIALS OF DRUGS HAVING MEMBRANE STABILIZING EFFECT ON INFILTRATION ANAESTHESIA IN GUINEA PIGS

摘要

Objective : To compare the local anaesthetic action of central neuron sodium channel blockers Phenytoin Sodium, Sodium Valproate and Carbamazepine with peripheral neuron sodium channel blockers Lignocaine using Infiltration anaesthesia in guinea pigs Material and Methods: In the present study,the local anaesthetic effect of Lignocaine with concentration of 0.2%, 0.1% ,0.05% was compared with Phenytoin Sodium, Sodium Valproate and Carbamazepine in concentrations of 0.2%, 0.1% ,0.05% using different dilutions of 0.05N,0.1N,0.2N HCL in guinea pig by pricking on the skin produces a squeak or movement indicating pain is produced. Results : The results of our present study suggest onset of local anaesthesia with lignocaine 0.2% is significantly fast when compared with concentration of 0.1%, and 0.05% indicating it has better efficacy when using for various local anaesthetic procedures. In addition onset of local anaesthesia with Phenytoin sodium concentrations of 0.2%, 0.1% ,0.05% is fast when compared with Sodium valproate concentrations of 0.2%, 0.1% ,0.05% and Carbamazepine concentrations 0.2%, 0.1% ,0.05%. Conclusion: Among antiepileptic drugs with local anaesthesia and membrane stabilizing activity Phenytoin sodium showed fast on set of action when compared with sodium valproate and Carbamazepine indicating it has better efficacy.