IMPROVED DISSOLUTION CHARACTERISTICS AND SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG BY NOVEL METHOD USING NATURAL GUM AND WATER SOLUBLE POLYMER

摘要

The main objective of the present study is too prepared, characterized and evaluate and surfactant used as a carrier in solid dispersions for enhancing the dissolution rate of simvastatin. The feasibility of formulating solid dispersions of pure drug with gum and surfactant combination that enhanced dissolution rate was also investigated. Solid dispersions of simvastatin in gum: surfactant different polymer ratios were prepared by kneading method and evaluated for dissolution rate and efficiency. All the solid dispersions prepared gave rapid and higher dissolution of simvastatin when compared with pure drug. The DE60 was also increased from many folds in the case of pure drug and solid dispersions. Experimental design was applied systematically and determine the influence of the individual and combined effect on independent variables (X1) ratio and (X2) concentration of surfactants on the dependent variables percent dissolution efficiency at 60 min (%DE 60) and yield percent and optimized formulation selected and characterised by its UV, Differential scanning caloriemetery, Scanning electron microscopy and X- Diffraction studies and formulated into capsule dosage form. In conclusion, the result of this work to suggest that solid dispersion is a useful technique for enhancing the solubility and dissolution study of water insoluble drug.