DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LEVOFLOXACIN HYDROCHLORIDE

摘要

Levofloxacin microspheres with mucoadhesive polymers like Sodium Alginate, Sodium Carboxymethyl Cellulose and Carbopol-940 were prepared by w/o emulsification solvent evaporation method and evaluated. The resulting microspheres were small, discrete, spherical and free flowing. The microspheres showed significant mucoadhesive property in the in-vitro wash-off test. The drug release from the mucoadhesive microspheres followed the controlled release profile. and first order kinetics. Drug release was controlled by the diffusion mechanism. Stability studies were performed at three different temperatures for six weeks. All the formulation showed satisfactory stability profile.