Correlation between TLR2, TLR3, TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns

摘要

Background This study was aimed to explore how toll‐like receptor 2 ( TLR2) , TLR3 , TLR4 and TLR9 influenced the risk and prognosis of severe hepatitis among the Chinese newborns. Methods Altogether 135 newborns diagnosed with severe hepatitis and 140 healthy newborns were included in this study. Totally 12 single nucleotide polymorphisms (SNPs) within TLR2 , TLR3 , TLR4 , and TLR9 were chosen and genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the logistic regression. The univariate and multivariate analyses were used to analyze independent factors for prognosis of severe hepatitis among the Chinese newborns. Results The SNPs within TLR2 [ie, rs1898830 (AG) and rs3804100 (TC)], TLR3 [ie, rs1879026 (GT)], TLR4 [ie, rs2149356 (TG)], and TLR9 [ie, rs187084 (TC), rs352139 (AG), and rs352140 (CT)] were significantly associated with modified risk of neonatal severe hepatitis (all P 1.5] of newborns with severe hepatitis (all P Conclusions Certain SNPs and haplotypes within TLR2 , TLR3 , TLR4 , and TLR9 can be considered as the potentially treatment targets for neonatal severe hepatitis.