Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

摘要

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean?±?SEM) aged 56.2?±?2.7 years, with a BMI of 24.5?±?1.5?kg/m2 and a VO2 peak of 28.7?ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4?h resting infusion, there was a greater () reduction in blood glucose in insulin treatment (INS) (from 11.2?±?0.6 to 5.6?±?0.1?mmol/l) than in saline treatment/control (CON) (from 11.5?±?0.7 to 8.5?±?0.6?mmol/l). This was associated with a lower () resting metabolic rate in INS (3.87?±?0.17) than in CON (4.39?±?0.30?kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6?±?0.1 at 0?min to 6.3?±?0.3?mmol/l at 30?min (), which was accompanied by a lower blood lactate response (). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.