Association of Genetic Variations in X-Ray Repair Cross-Complementing Group 1 and Tourette Syndrome

摘要

X-ray repair cross-complementing group 1 (XRCC1) plays a central role in mammalian DNA repair process. The polymorphism rs25487 (ArgGln at codon 399) of this gene is common in Han Chinese population.ObjectivesThe objective of this study was to analyze the association between this functional SNP of XRCC1 and Tourette syndrome (TS) in Han Taiwan Chinese population.MethodsGenotyping was performed by using PCR–RFLP method on 73 TS patients and 158 normal controls.ResultsOur data indicated that genotype frequency of A/G polymorphism at codon 399 of the patients differed from the controls (P = 0.026, OR: 2.22, 95% CI: 1.22–4.03). The allele frequency analysis also showed significant differences with higher A allele frequency in patients (P = 0.015, OR: 1.70, 95% CI: 1.11–2.62).ConclusionOur study indicates that the functional SNP at codon 399 of XRCC1 is associated with TS development. J. Clin. Lab. Anal. 26:321-324, 2012. ? 2012 Wiley Periodicals, Inc.