Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

摘要

Objectives:The aim of the this study was to investigate the relationship between the degree of mitral regurgita -tion (MR), left ventricular (LV) dysfunction determined by strain (S)/strain rate (SR) imaging and plasma brain natri -uretic peptide (BNP) levels.Materials and methods:This is an observational cross-sectional study which included 31 consecutive patients (15[48.4%] male) who had applied to our outpatient clin -ics and diagnosed as mitral regurgitation and 25 (12 [48.0%] male) healthy persons as control subjects. The mitral regurgitation patients were divided into two groups: those with moderate MR (n=14[45.2%]) and those with severe MR (n=17[54.8%]), and maximum strain / strain rate measurements of left ventricular wall segments and plasma brain natriuretic peptide levels were determined in these two groups and controls. Results:S/SR values of all wall segments of left ventricle were found to be decreased in patient with severe MR when compared with the control subjects and patients with moderate MR (p<0.001).Conclusions: Although left ventricle functions with con -ventional echocardiography in patients with mitral valve regurgitation were normal, subclinic deteriorations of left ventricle were detected in patients with severe mitral valve regurgitation